Working proteins make good use of frustration

Computational surveys show that after folding enzymes still remain partially frustrated at their active site to allow catalysis targeting. Parts of the protein distant from the enzymatic center also show evidence of frustration to support the active site.

Working proteins make good use of frustration

Proteins fold according to a script written in the pattern of their amino acids. But to function properly, some parts must ad-lib.

Mon 11 Feb 19 from Phys.org

Working proteins make good use of frustration, Mon 11 Feb 19 from Eurekalert

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